You probably won’t need distrobox much unless you’re a dev. Most packages will be available as a flatpak or in homebrew. You could also consider using Nix, which will most likely have every package you’d want.

One of ublue’s offerings are probably best. Immutability is great for resiliency and updates are easily rolled back if something were to go wrong. Bazzite is great for gaming, otherwise checkout Aurora and Bluefin.